Thermo Fisher Scientific MEPCE Polyclonal Antibody
Human MEPCE 단백질을 인식하는 Goat Polyclonal Antibody로, Western Blot에 검증됨. 합성 펩타이드(aa 666-678)를 면역원으로 사용. 액상 형태, 0.5 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications
- Western Blot (WB): 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (TPHNTSKGFQRP) corresponding to the internal amino acids of MEPCE (aa 666–678) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10980667 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to its stabilization (PubMed:17643375, PubMed:19906723, PubMed:30559425).
Also has a non-enzymatic function as part of the 7SK RNP complex, which sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive complex, preventing RNA polymerase II phosphorylation and transcriptional elongation (PubMed:17643375).
The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838).
In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate complex assembly (PubMed:19906723).
Interaction with LARP7 within the 7SK RNP complex occludes its catalytic center (PubMed:19906723).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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