Thermo Fisher Scientific MEPCE Polyclonal Antibody

Applications

• Western Blot (WB): 0.3–1 µg/mL

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.

Target Information

S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to its stabilization (PubMed:17643375, PubMed:19906723, PubMed:30559425).
Also has a non-enzymatic function as part of the 7SK RNP complex, which sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive complex, preventing RNA polymerase II phosphorylation and transcriptional elongation (PubMed:17643375).
The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838).
In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate complex assembly (PubMed:19906723).
Interaction with LARP7 within the 7SK RNP complex occludes its catalytic center (PubMed:19906723).
[UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.