Thermo Fisher Scientific NEDD4 Polyclonal Antibody
NEDD4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 동결건조 형태로 제공되며 연구용으로 사용됩니다.
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Thermo Fisher Scientific NEDD4 Polyclonal Antibody
Applications
- Western Blot (WB): 0.1–0.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived human NEDD4 recombinant protein (Position: N960–F1245) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 4 mg trehalose |
| Contains | 0.05 mg sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2746840 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains.
It participates in the degradation pathway of VEGFR-2/KDFR independently of its ubiquitin-ligase activity.
Acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, similar to Mdm2 and p53 regulation.
Also involved in viral budding and regulation of epithelial Na⁺ channels associated with arterial hypertension.
Localized to the sarcolemmal region of muscle fibers; increased expression leads to muscle unloading and denervation with decreased Notch1 expression, acting as a down-regulator of Notch-1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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