Thermo Fisher Scientific NEDD4L Polyclonal Antibody
Thermo Fisher Scientific의 NEDD4L Polyclonal Antibody는 인간, 마우스, 랫트에 반응하는 Rabbit IgG 기반 항체입니다. Western blot, IHC, ICC, Flow cytometry 등에 사용 가능하며, E. coli 유래 NEDD4L 단백질을 면역원으로 제작되었습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 0.5–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.5–1 µg/mL |
| Flow Cytometry (Flow) | 1–3 µg/1×10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived human NEDD4-2 recombinant protein (Position: N703–D975) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 4 mg trehalose |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2746841 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
NEDD4L is an E3 ubiquitin-protein ligase that transfers ubiquitin from an E2 conjugating enzyme to target substrates. It inhibits TGF-beta signaling by inducing SMAD2 and TGFR1 ubiquitination and degradation. NEDD4L also mediates ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav, Kv, EAAT1, and CLC5, and promotes degradation of SGK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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