Thermo Fisher Scientific RUNX2 Polyclonal Antibody
RUNX2 단백질을 인식하는 염소 유래 폴리클로날 항체로, Western blot 및 IHC에 사용 가능. 인간, 마우스, 랫트에 반응하며, 골형성 및 골아세포 분화 연구에 적합. 동결건조 형태로 제공되며 장기 보관 시 -20°C 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Goat / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from internal region of mouse Runx2 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in human and rat.
- Specificity: Runx2.
Target Information
RUNX2 is a nuclear transcription factor belonging to the RUNX family, containing a Runt DNA-binding domain. It is essential for both membranous and endochondral bone formation, regulating osteoblastic differentiation and skeletal morphogenesis. RUNX2 also functions as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. It binds DNA as a monomer or as part of a heterodimeric complex, enhancing TGFBR1 expression in osteoblasts and cooperating with DLX5 or related factors to activate osteoblast-specific genes. Mutations in RUNX2 are associated with cleidocranial dysplasia (CCD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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