Thermo Fisher Scientific Tnfaip6 Polyclonal Antibody

Thermo Fisher Scientific Tnfaip6 Polyclonal Antibody

Product Specifications

Product Specific Information

• Immunogen sequence:
  DDPGCLADYV EIYDSYDDVH GFVGRYCGDE LPDDIISTGN VMTLKFLSDA SVTAGGFQIK YVAMDPVSKS SQ
• Highest antigen sequence identity:
  • Mouse: 93%
  • Rat: 90%

Target Information

The TSG6 gene is transcribed in normal fibroblasts and activated by cytokines TNF alpha and IL-1 at AP-1 and NF-IL6 promoter sites.
TSG-6 is a glycoprotein belonging to the hyaluronan-binding protein family, including cartilage link protein, proteoglycan core protein, and CD44.
It is highly homologous to CD44, especially in the hyaluronic acid-binding domain.
TSG-6 is expressed in TNF-treated cells and is rapidly activated by TNF alpha, IL-1, and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells, and chondrocytes.
Its presence in synovial fluid suggests a possible role in rheumatoid arthritis.
TSG-6 forms a stable complex with components of the serine protease inhibitor inter-alpha-inhibitor (IαI) and enhances its inhibitory effect on plasmin protease activity.
Through their cooperative inhibitory effect, TSG-6 and IαI modulate the protease network and help inhibit inflammation.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.