Thermo Fisher Scientific MLCK Polyclonal Antibody
MLCK 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. IHC, ICC/IF, Flow Cytometry, ELISA 등 다양한 응용에 사용 가능하며, Protein A로 정제된 액상 형태입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human MLCK, amino acids 651–750 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MLCK (also known as MYLK3) is a member of the myosin regulatory light chain kinases that facilitate muscle contraction. It belongs to the Ser/Thr protein kinase family and is responsible for smooth muscle contraction through phosphorylation of a specific serine in the N-terminus of myosin light chains (MLC), promoting interaction with actin filaments.
MLCK plays a key role in vascular permeability and tissue edema formation. In the nervous system, it regulates astrocytic process growth and neurotransmitter release at sympathetic synapses. It is also involved in fibroblast apoptosis signaling.
Both smooth muscle and non-muscle isoforms are widely expressed in adult and fetal tissues, with non-muscle isoform 2 being predominant. The Telokin isoform, which binds calmodulin, is also broadly expressed. MLCK likely undergoes down-regulation via phosphorylation and contains one fibronectin type III domain and nine immunoglobulin-like C2-type domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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