Thermo Fisher Scientific beta-1 Adrenergic Receptor Polyclonal Antibody
Rabbit polyclonal antibody targeting beta-1 adrenergic receptor. Validated for WB, IHC, ICC/IF with broad species reactivity. Liquid form, 1 mg/mL concentration. Suitable for cardiac and receptor signaling research.
- 카탈로그번호
- PA528808
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | – |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Human, Pig |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 414–477 of Human beta-1 Adrenergic Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2546284 |
Product Specific Information
- Recommended positive controls: A431, H1299
- Predicted reactivity: Rhesus Monkey (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. These receptors exhibit significant heterogeneity, with nine subtypes identified: three alpha-1 (1A/D, 1B, 1C), three alpha-2 (2A, 2B, 2C), and three beta (1, 2, 3).
ARs are involved in disease states such as hypertension, cardiac dysfunction, diabetes, glaucoma, depression, and impotence. Beta-adrenergic receptors (BARs) regulate development, behavior, cardiac function, smooth muscle tone, and metabolism. Knockout studies of the B1AR gene show prenatal lethality and cardiac abnormalities. Thyroid hormones and catecholamine-sensitive adenylyl cyclase modulate B1AR transcription. cAMP and CREM family transcription factors further influence B1AR regulation.
⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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