Thermo Fisher Scientific beta-1 Adrenergic Receptor Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: A431, H1299
• Predicted reactivity: Rhesus Monkey (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. These receptors exhibit significant heterogeneity, with nine subtypes identified: three alpha-1 (1A/D, 1B, 1C), three alpha-2 (2A, 2B, 2C), and three beta (1, 2, 3).

ARs are involved in disease states such as hypertension, cardiac dysfunction, diabetes, glaucoma, depression, and impotence. Beta-adrenergic receptors (BARs) regulate development, behavior, cardiac function, smooth muscle tone, and metabolism. Knockout studies of the B1AR gene show prenatal lethality and cardiac abnormalities. Thyroid hormones and catecholamine-sensitive adenylyl cyclase modulate B1AR transcription. cAMP and CREM family transcription factors further influence B1AR regulation.

⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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