Thermo Fisher Scientific HCN1 Polyclonal Antibody
HCN1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 생쥐 시료에 반응합니다. Western blot과 IHC(Paraffin) 실험에 적합하며, 동결건조 형태로 제공됩니다. 연구용으로만 사용되며 장기 보관 시 -20°C에서 안정적입니다.
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Thermo Fisher Scientific HCN1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human HCN1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in mouse and marmoset.
- Specificity: HCN1.
Target Information
HCN1 (Hyperpolarization-activated cation channel 1) is part of the HCN gene family, contributing to spontaneous rhythmic activity in both heart and brain. These pacemaker channels are activated by hyperpolarization and regulated by cyclic nucleotides.
HCN1 and HCN2 are essential for motor learning and neuronal integration by cerebellar Purkinje cells, shaping autonomous neuronal activity and network oscillations.
HCN1 expression is enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus.
HCN2 is abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body.
Regional specificity of HCN channels may contribute to differences in neuronal pacemaker activity across brain systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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