Thermo Fisher Scientific KITLG Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

in situ PLA (PLA)

• Tested Dilution: 1:1200

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MKKTQTWILT CIYLQLLLFN PLVKTEGICR NRVTNNVKDV TKLVANLPKD YMITLKYVPG MDVLPSHCWI SEMVVQLSDS LTDLLDKFSN ISEGLSNYSI IDKLVNIVDD LVECVKENSS KDLKKSFKSP EPRLFTPEEF FRIFNRSIDA FKDFVVASET SDCVVSSTLS PEKGKAKNPP GDSSLHWAAM ALPALFSLII GFAFGALYWK KRQPSLTRAV ENIQINEEDN EISMLQEKER EFQEV

Target Information

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways.
Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and activation of signaling pathways such as PI-3, PLC-γ, Jak/STAT, and MAP kinase pathways.
SCF expression induces mast cell survival and the release of histamine, pro-inflammatory cytokines, and chemokines.
Inhibition of the SCF/c-Kit pathway decreases histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting its potential as a therapeutic target in inflammatory diseases such as asthma.
At least two isoforms of SCF are known to exist.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.