Thermo Fisher Scientific KLF4 Recombinant Rabbit Monoclonal Antibody (BLR250L)

Thermo Fisher Scientific KLF4 Recombinant Rabbit Monoclonal Antibody (BLR250L)

Applications and Tested Dilutions

• Western Blot (WB): 1:1,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:100–1:500
• Immunocytochemistry (ICC/IF): 1:100–1:500
• Immunoprecipitation (IP): 6 µL/mg of lysate

Product Specifications

Product Specific Information

Immunocytochemistry: Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

Target Information

Kruppel-like factor 4 (KLF4) protein is encoded by the KLF4 gene located on chromosome 9 in humans. Also known as gut-enriched Kruppel-like factor (GKLF) or epithelial zinc-finger protein (EZF), it belongs to the Kruppel-like factor family of DNA-binding zinc finger transcription factors.
KLF4 plays a key role in cellular processes such as endothelial signaling, adipogenesis, differentiation, embryogenesis, and cell cycle control. As one of the four Yamanaka factors, it is crucial for reprogramming differentiated cells into pluripotent stem cells.
Its localization determines biological significance—nuclear localization is associated with oncogenic function, while cytosolic localization correlates with tumor suppression effects.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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