Thermo Fisher Scientific CD4 (T-Helper/Inducer Cell Marker) Monoclonal Antibody (CD4/7144)
인간 CD4 단백질을 인식하는 마우스 단클론 항체로, T-helper 세포 마커 분석에 적합합니다. IHC(파라핀, PFA 고정)에 최적화되어 있으며, Protein A/G로 정제된 액상 형태입니다. 4°C 보관, 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CD4/7144 |
| Immunogen | Recombinant fragment (around aa200–400) of human CD4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The CD4 antigen is involved in the recognition of MHC class II molecules and serves as a co-receptor for HIV. CD4 is primarily expressed in T-helper lymphocytes but can also be found in monocytes, macrophages, and dendritic cells.
At the tissue level, CD4 expression is observed in thymus, lymph nodes, tonsils, spleen, and certain regions of the brain and gut.
CD4 contributes to the initiation and amplification of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase Lck.
It may also act as a mediator of neuronal damage in infectious and immune-mediated CNS diseases.
Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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