Thermo Fisher Scientific HEXB chain A Polyclonal Antibody
HEXB chain A를 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며, 고순도 Protein A 정제 및 안정적인 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human HEXB chain A, amino acids 451–556 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of ganglioside GM2 and other molecules containing terminal N-acetyl hexosamines.
Beta-hexosaminidase consists of alpha and beta subunits encoded by separate genes. Both belong to family 20 of glycosyl hydrolases. Mutations in these genes cause accumulation of GM2 ganglioside in neurons, leading to neurodegenerative disorders known as GM2 gangliosidoses.
Mutations in the beta subunit gene result in Sandhoff disease (GM2-gangliosidosis type II).
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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