Thermo Fisher Scientific NECAB3 Polyclonal Antibody
NECAB3 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot 및 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 골지체 단백질 연구에 유용합니다. 액상 형태로 -20°C 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–362 of human NECAB3 (NP_1125083) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.76 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806105 |
Product Specific Information
Immunogen sequence:
MACAGLLTVC LLRPPAPQPQ PQTPRHPQLA PDPGPAGHTL FQDVFRRADK NDDGKLSFEE FQNYFADGVL SLGELQELFS GIDGHLTDNL ETEKLCDYFS EHLGVYRPVL AALESLNRAV LAAMDATKLE YERASKVDQF VTRFLLRETV SQLQALQSSL EGASDTLEAQ AHGWRSDAES VEAQSRLCGS RRAGRRALRS VSRSSTWSPG SSDTGRSSEA EMQWRLQVNR LQELIDQLEC KAPRLEPLRE EDLAKGPDLH ILMAQRQVQV AEEGLQDFHR ALRCYVDFTG AQSHCLHVSA QKMLDGASFT LYEFWQDEAS WRRHQQSPGS KAFQRILIDH LRAPDTLTTV FFPASWWIMN NN
Positive Samples: LO2, Mouse liver, Rat liver
Cellular Location: Golgi apparatus
Target Information
The NECAB3 protein interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibiting its association with amyloid precursor protein (APP) through a non-competitive mechanism. This interaction abolishes the suppression of beta-amyloid production by X11L. NECAB3 and X11L together may play a key role in regulating APP metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2 and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been identified.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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