Thermo Fisher Scientific B4GALT5 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: QGLDGLNNLN YFANITYDAL YKNITVNLTP ELAQVNEY
• Antigen sequence identity: Mouse 92%; Rat 89%

Target Information

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that have exclusive specificity for the donor substrate UDP-galactose. All transfer galactose in a beta1,4 linkage to similar acceptor sugars such as GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures.

As type II membrane proteins, they possess an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and remains uncleaved to function as a transmembrane anchor.

By sequence similarity, the beta4GalTs form four groups:

• beta4GalT1 and beta4GalT2
• beta4GalT3 and beta4GalT4
• beta4GalT5 and beta4GalT6
• beta4GalT7

The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature, it is also referred to as beta4GalT2.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.