Thermo Fisher Scientific GUCY1B3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
ISPYTFCKAF PFHIIFDRDL VVTQCGNAIY RVLPQLQPGN CSLLSVFSLV RPHIDISFHG ILSHINTVFV LRSKEGLLDV EKLECEDELT GTEISCLRLK GQMIYLPEAD SILFLCSPSV MNLDDL

Antigen sequence identity:
Mouse 98%; Rat 98%

Target Information

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase: a soluble form (GCS or sGC), which acts as receptors for nitric oxide, and a membrane-bound receptor form (GC), which are peptide hormone receptors.
The GC-C protein includes an extracellular domain, a single transmembrane domain, and a cytoplasmic region with kinase-like and catalytic domains. It exists as two glycosylated forms: a 130 kDa precursor in the endoplasmic reticulum and a 145 kDa form on the plasma membrane.
Ligand binding to the extracellular domain promotes cGMP accumulation. GC-C acts as a receptor for heat-stable enterotoxins from pathogenic E. coli, causing secretory diarrhea, and also binds guanylin and uroguanylin peptides that regulate renal function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.