Thermo Fisher Scientific EFHA1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 200-300 of human MICU2 (NP_6899391) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:EFHA1,uniProtId:Q8IYU8-1,ncbiNodeId:9606,antigenRange:215-231,antigenLength:434,antigenImageFileName:PA5-88410_EFHA1_Q8IYU8-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88410_EFHA1_Q8IYU8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.58 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804893

Product Specific Information

Positive Samples: 293T, Mouse skeletal muscle, Rat skeletal muscle; Cellular Location: Mitochondrion intermembrane space

Immunogen sequence: TNETGYQEAI VKEPEIN

Target Information

Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.