Thermo Fisher Scientific MSL1 Polyclonal Antibody
Human MSL1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 및 글리세롤 버퍼에 보존됩니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MSL1 (Product #RP-93536) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644231 |
Product Specific Information
Immunogen sequence:
QQQQLQAKEK EIEELKSERD TLLARIERME RRMQLVKKDN EKERHKLFQG YETEEREETE LSEKIKLECQ PELSETSQTL PPKPFSCGRS GKGHK
- Highest antigen sequence identity to orthologs:
- Mouse: 92%
- Rat: 94%
Target Information
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at Lys-16 (H4K16ac), which is implicated in formation of higher-order chromatin structure (PubMed:16227571).
Enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at Lys-34 (H2BK34Ub) (PubMed:21726816).
This modification stimulates histone H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including HOXA9 and MEIS1 (PubMed:21726816).
In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026).
[Source: UniProt]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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