Thermo Fisher Scientific ID3 Monoclonal Antibody (OTI8B3), TrueMAB
ID3 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC/IF, Flow Cytometry에 적합. 고순도의 액상 항체로 PBS/BSA/glycerol buffer에 보존. 연구용으로 세포 성장 및 분화 관련 ID3 단백질 분석에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8B3 |
| Immunogen | Full length human recombinant protein of human ID3 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Members of the Id family of basic helix-loop-helix (bHLH) proteins include ID1, ID2, ID3, and ID4. They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins. Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. Thus, ID-type proteins negatively regulate DNA binding of bHLH proteins.
ID1 inhibits DNA binding of E12 and Myo D, thereby inhibiting muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, ID protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, activating myogenic differentiation. Expression of each ID protein is strongly dependent on growth factor activation, and reduction of ID mRNA levels by antisense oligonucleotides delays reentry of arrested cells into the cell cycle following growth factor stimulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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