Thermo Fisher Scientific HTR1B (extracellular) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitute antibody with 50 µL of double distilled water (DDW).
• The reconstituted solution can be stored at 4°C for up to 1 week.
• For longer periods, store small aliquots at -20°C.
• Avoid multiple freeze-thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Peptide sequence: CSAKDYIYQDSISLPWK
Homology:

• Rat: 15/17 amino acid residues identical
• Mouse: 14/17 amino acid residues identical

Target Information

Serotonin (5-hydroxytryptamine, 5-HT) plays key roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular, and gastrointestinal systems. Molecular cloning studies have identified five receptors belonging to the 5-HT1 subtypes, which are negatively coupled to adenylyl cyclase.
Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior colliculus. In situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus, and lower levels in caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.