Thermo Fisher Scientific PD-L2 Recombinant Rabbit Monoclonal Antibody (BLR277L)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Immunocytochemistry: Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

Target Information

Programmed death-ligand 2 (PD-L2), also known as B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily. Along with PD-L1, it serves as a ligand for PD-1. PD-L2 is primarily expressed in dendritic cells but can be induced in various immune and non-immune cells depending on the microenvironment.
Its expression increases particularly in response to IL-4 and, to a lesser extent, TNF-α and IFN-γ. Although expressed at lower levels than PD-L1, PD-L2 has a 2–6 times higher affinity for PD-1.
PD-1 and its ligands act as inhibitory immune checkpoint molecules, regulating immune homeostasis by inhibiting T cell activation, proliferation, and cytokine secretion. Interestingly, PD-L2 can also stimulate T cell proliferation and cytokine production independently of PD-1, suggesting additional receptors.
Recent studies identified repulsive guidance molecule b (RGMb) as a second receptor for PD-L2, involved in respiratory tolerance through BMP and/or neogenin signaling pathways.
The human PD-L2 monomer consists of a 201-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 32-amino-acid cytoplasmic domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.