Thermo Fisher Scientific CDCA2 Polyclonal Antibody
CDCA2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat 시료에 반응하며, Protein A로 정제된 액상 형태입니다. 세포 분열 및 암 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human CDCA2 (amino acids 361–450) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cell division cycle associated 2 (CDCA2, also known as Repo-Man) is a cell-cycle protein that recruits protein phosphatase 1 (PP1) to mitotic chromatin at anaphase onset, which is essential for cell proliferation. Phosphorylation of CDCA2 at Ser893 by Aurora B inhibits its function, while dephosphorylation by PP2A allows reformation of the CDCA2/PP1 complex. This complex is required for chromatin binding and histone H3 dephosphorylation at Thr3, Ser10, and Ser28, and plays a role in nuclear envelope reformation during mitotic exit. CDCA2 also participates in DNA repair by promoting DNA damage response upon release from chromatin. Elevated CDCA2 expression has been observed in several cancers, including melanoma, neuroblastoma, squamous cell carcinoma, and synovial sarcoma, suggesting its potential as a prognostic marker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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