Thermo Fisher Scientific CD98 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1-10 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

15-25 µg/mL

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

4°C or -20°C if preferred

Shipping conditions

Wet ice

RRID

AB_2190984

Product Specific Information

Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. A suggested positive control for immunohistochemical applications is placenta. In Western blot, this antibody detects a band at ~50-55kDa in human liver cell lysate.

Rabbit anti Human CD98 light chain antibody detects an epitope within the N-terminal (NT) region of the CD98 light chain (CD98LC), also known as the 4F2 light chain, or LAT-1.

Target Information

CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. It is implicated in regulation of cellular differentiation, growth and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.