Thermo Fisher Scientific GNAO1 Polyclonal Antibody
GNAO1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 실험에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 신경조직 연구 및 G 단백질 관련 신호전달 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within human GNAO1 aa 1–200 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913397 |
Product Specific Information
- Positive Control: Rat brain tissue lysate, mouse brain tissue lysate, mouse hippocampus tissue lysate, human brain tissue lysate, human pancreas tissue
- Subcellular Location: Cell membrane, Membrane
Target Information
Heterotrimeric G proteins are membrane-bound GTPases linked to 7-transmembrane receptors. Each G protein contains alpha-, beta-, and gamma-subunits and is bound to GDP in the "off" state. Ligand–receptor binding causes detachment of the G protein, switching it to an "on" state and allowing Galpha activation of second messenger signaling cascades.
There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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