Thermo Fisher Scientific PDCD1/PD1/CD279 (Programmed Cell Death 1) Recombinant Rabbit Monoclonal Antibody (PDCD1/7255R)

Applications

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1–2 µg/mL

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is self-limited, as activated T cells express receptors such as PD-1 (PDCD-1) that mediate inhibitory signals from the APC. PD-1 binds two related ligands, PDL-1 and PDL-2, and upon binding, inhibits immune activation in the absence of danger signals such as LPS or bacterial molecules. PD1-deficient mice exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.