Thermo Fisher Scientific PLAU Monoclonal Antibody (OTI5H4), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The PLAU gene encodes a serine protease involved in extracellular matrix degradation and may play a role in tumor cell migration and proliferation.
A specific polymorphism in this gene has been associated with late-onset Alzheimer’s disease and altered fibrin-binding affinity.
This protein converts plasminogen to plasmin by cleaving an Arg-Val bond. Plasmin subsequently cleaves this protein into a two-chain derivative (HMW-uPA), connected by a disulfide bond between the A- and B-chains.
HMW-uPA can be further processed into LMW-uPA, which remains proteolytically active but does not bind the uPA receptor.
Alternative splicing results in multiple isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.