Thermo Fisher Scientific Urokinase Recombinant Rabbit Monoclonal Antibody (10E5)
Recombinant rabbit monoclonal antibody targeting human Urokinase (clone 10E5). Validated for IHC and ELISA. High purity via affinity chromatography. Supplied as liquid form with 3.1 mg/mL concentration. Suitable for research use only.
- 판매단위
- pk
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Thermo Fisher Scientific Urokinase Recombinant Rabbit Monoclonal Antibody (10E5)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10E5 |
| Immunogen | A synthesized peptide derived from human Urokinase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C or −80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092716 |
Target Information
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer’s disease and also with decreased affinity for fibrin-binding.
This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative (HMW-uPA) connected by a single disulfide bond between the amino-terminal A-chain and the catalytically active, carboxy-terminal B-chain.
HMW-uPA can be further processed into LMW-uPA by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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