Thermo Fisher Scientific Phospho-IRS1 (Tyr612) Polyclonal Antibody
Phospho-IRS1 (Tyr612) 항체는 인간, 마우스, 랫트 반응성을 가지며 Western blot 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제된 비결합형 폴리클로날 항체로, 인슐린 신호전달 연구에 유용합니다. -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | 48 publications |
| Immunohistochemistry (IHC) | - | 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:100 | 1 publication |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | - | 3 publications |
| Immunoprecipitation (IP) | - | 2 publications |
| Functional Assay | - | 1 publication |
| Miscellaneous PubMed | - | 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from human IRS-1 containing tyrosine 612. Sequence conserved in mouse, rat, and chicken. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533768 |
Product Specific Information
On Western blotting, this antibody detects a protein with an apparent molecular weight of 165 kDa.
Positive controls: Insulin (50 nM for 5 min) or TPA (100 ng/mL for 30 min) treated human embryonic kidney cells (293T) or CHO-T cells transiently transfected with a plasmid encoding human IRS1.
Target Information
IRS-1 is a major substrate of the insulin receptor and is phosphorylated in response to insulin, IGF-1, and IL-4 stimulation.
It undergoes phosphorylation on serine, threonine, and tyrosine residues in various tissues.
Casein kinase II mediates insulin-stimulated serine/threonine phosphorylation of IRS-1, with Thr 502 and Ser 99 identified as major phosphorylation sites.
IRS-1 contains three putative 14-3-3 binding sites (Ser 270, Ser 374, Ser 641), with the Ser 270 motif located in the phosphotyrosine binding domain responsible for insulin receptor interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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