Thermo Fisher Scientific NEK8 Polyclonal Antibody
Rabbit Polyclonal NEK8 항체로 Western blot에 적합하며, 293T, HeLa 등 다양한 세포주에서 사용 가능. Human NEK8 아미노산 1–214 영역 기반 면역원 사용. Mouse, Rat 등 다종 교차 반응 예측. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–214 of Human NEK8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4 °C short term. For long term storage, store at −20 °C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546898 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLa, Molt-4
- Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (89%), Xenopus laevis (93%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
NEK8 (NIMA-related kinase 8)
NEK8 serine/threonine kinase is related to NIMA (never in mitosis, gene A) of Aspergillus nodulins and may play a role in cell cycle progression from G2 to M phase. NEK8 is part of a complex of ciliary proteins required for renal and cardiovascular development. It interacts with polycystin signaling pathways and may control the targeting of ciliary proteins. NEK8 is required for renal tubular integrity and may regulate local cytoskeletal structure in kidney tubule epithelial cells, as well as ciliary biogenesis through protein targeting.
Defects in NEK8 cause nephronophthisis type 9 (NPHP9) [MIM:613824], an autosomal recessive disorder leading to end-stage renal disease characterized by tubular modifications, basement membrane thickening, interstitial fibrosis, and medullary cysts.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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