Thermo Fisher Scientific DMTF1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Peptide sequence:
SFNDAHVSKF SDQNSTELMN SVMVRTEEEI SDTDLKQEES PSDLASAYVT

Sequence homology:
Dog: 92%
Guinea Pig: 91%
Horse: 92%
Human: 100%
Mouse: 92%
Rabbit: 92%
Rat: 92%

Target Information

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.