Thermo Fisher Scientific BTRC Monoclonal Antibody (OTI1D4), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:500

Product Specifications

Target Information

This gene encodes a member of the F-box protein family characterized by an approximately 40 amino acid motif, the F-box.
F-box proteins form one of the four subunits of the ubiquitin protein ligase complex SCFs (SKP1-cullin-F-box), functioning in phosphorylation-dependent ubiquitination.
The F-box proteins are divided into 3 classes:

1. Fbws – containing WD-40 domains
2. Fbls – containing leucine-rich repeats
3. Fbxs – containing other protein-protein interaction modules or no recognizable motifs

The encoded protein belongs to the Fbws class and contains multiple WD-40 repeats. It is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2, and Drosophila Slimb proteins.
It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery.
Additionally, it associates with phosphorylated IkappaBalpha and beta-catenin destruction motifs, functioning in transcriptional regulation by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.