Thermo Fisher Scientific BTRC Monoclonal Antibody (OTI3D5), TrueMAB
인간 BTRC 단백질(aa 52–354)에 특이적인 Mouse IgG1 단클론 항체. Western blot과 면역세포화학(ICC/IF)에 적합. 친화 크로마토그래피로 정제된 액상 형태로, 안정적인 PBS/BSA/glycerol 버퍼에 보존. 연구용으로만 사용 가능.
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Thermo Fisher Scientific BTRC Monoclonal Antibody (OTI3D5), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3D5 |
| Immunogen | Human fragment corresponding to amino acids 52–354 of human BTRC produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.75 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The BTRC gene encodes a member of the F-box protein family characterized by an approximately 40 amino acid motif, the F-box. These proteins are components of the SCF (SKP1–Cullin–F-box) ubiquitin ligase complex, which mediates phosphorylation-dependent ubiquitination.
F-box proteins are classified into three groups:
- Fbws: Containing WD-40 domains
- Fbls: Containing leucine-rich repeats
- Fbxs: Containing other interaction modules or no recognizable motifs
The BTRC protein belongs to the Fbws class and contains multiple WD-40 repeats. It is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2, and Drosophila Slimb proteins.
It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery, and associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs.
This protein likely functions in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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