Thermo Fisher Scientific CD38 Polyclonal Antibody
Human CD38 단백질에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용 가능. 고순도 항원 친화 크로마토그래피 정제. 액상 형태로 안정적이며, 장기 보관 시 -20°C에서 보관 권장. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CD38 (control fragment Product #RP-88813) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789947 |
Product Specific Information
Immunogen Sequence:
AACDVVHVML NGSRSKIFDK NSTFGSVEVH NLQPEKVQTL EAWVIHGGRE DSRDLCQDPT IKELESIISK RNIQFSCKNI YRPDKFLQCV KNPEDSSCTS EI
Target Information
CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells.
It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD⁺ glycohydrolase, or as a cell surface receptor.
Antibodies to CD38 are useful for:
- Subtyping lymphomas and leukemias
- Detection of plasma cells (e.g., identification of myelomas)
- Marking activated B and T cells
CD38 participates in cell adhesion, signal transduction, and calcium signaling. It is highly expressed in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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