Thermo Fisher Scientific CDK9 Polyclonal Antibody
CDK9 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, WB 및 ICC/IF에 적합합니다. 인간, 생쥐, 제노푸스 반응성을 가지며, 0.4 mg/mL 농도의 액상 형태로 제공됩니다. 세포 주기 및 전사 조절 연구용으로 최적화된 항체입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:250–1:500
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Xenopus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 150–250 of Human CDK9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10978653 |
Product Specific Information
This antibody is predicted to react with mouse, rat, chicken, and cow based on sequence homology.
Target Information
CDK9 is a serine/threonine kinase which, when complexed with CyclinT1, forms an active holoenzyme complex that regulates the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1 and regulates cytokine-inducible transcription networks by facilitating promoter recognition of target transcription factors. It promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity toward the CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and predisposition to heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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