Thermo Fisher Scientific ADAM15 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa, HepG2, Molt-4, NIH-3T3
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) family. ADAM proteins are type I transmembrane glycoproteins involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules.
This protein contains multiple functional domains including:

• Zinc-binding metalloprotease domain
• Disintegrin-like domain
• EGF-like domain

Through its disintegrin-like domain, it interacts with the integrin beta chain (beta 3) and Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting roles in cell-cell adhesion and cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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