Thermo Fisher Scientific Phospho-CCR5 (Ser349) Polyclonal Antibody
인간 CCR5 단백질의 Ser349 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며, 1 mg/mL 농도의 액상 형태로 제공. HIV 연구 및 CCR5 관련 신호전달 연구에 적합. -20°C에서 보관, Wet ice 조건으로 배송.
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Thermo Fisher Scientific Phospho-CCR5 (Ser349) Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human CCR5 around the phosphorylation site of Ser349 (E-I-SP-V-G) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554684 |
Target Information
Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, and CCR8 in the chemokine receptor family, as well as GPR15, STRL33, GPR1, and V28, were identified as HIV coreceptors.
Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains, facilitating fusion and entry into human white blood cells. CCR5 is required for infection by HIV-1, HIV-2, and SIV.
The beta-chemokines RANTES, MIP-alpha, and MIP-beta are ligands for CCR5 and prevent infection by M-tropic HIV-1. CCR5 associates with the surface CD4-gp120 complex of HIV, leading to membrane fusion and viral entry. The amino-terminal domain and extracellular loops of CCR5 serve as HIV binding sites. CCR5 mRNA is expressed in lymphoid organs and monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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