Thermo Fisher Scientific GAS2 Polyclonal Antibody
Human GAS2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 Immunoprecipitation에 사용 가능. 방부제 무첨가로 고순도 정제. 세포골격 및 세포사멸 연구에 적합. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunoprecipitation (IP) | 1–2 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the N-terminus of the Human GAS2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787946 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human GAS2.
Target Information
Gas2 is a 313 amino acid protein encoded by the human gene GAS2. It plays a role in apoptosis as a substrate for caspases and is a component of the microfilament system. Gas2 is cleaved by caspase-3 and caspase-7 at Asparagine 278 during apoptosis, leading to rearrangement of the actin cytoskeleton and changes in cell shape.
Gas2 is involved in membrane ruffling and is phosphorylated on serine residues during the G0–G1 transition. It co-localizes with actin fibers at the cell border and along stress fibers in growth-arrested fibroblasts. Gas2 is mainly membrane-associated but accumulates at membrane ruffles when hyperphosphorylated. It is expressed ubiquitously, with highest levels in liver, lung, and kidney.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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