Thermo Fisher Scientific FIS1 Monoclonal Antibody (GT9810)
FIS1 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (GT9810). Western blot 및 Immunocytochemistry에 적합하며 Human, Mouse 반응성. 고농도(1.9 mg/mL) 액상 형태로 제공, Protein G 정제, 장기보관 시 -20°C 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:20,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT9810 |
| Immunogen | Full length human FIS1 recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.9 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2735186 |
Product Specific Information
- Positive Control: HeLa, NCI-H929
- Predicted Reactivity: Mouse (96%), Rat (87%), Rhesus Monkey (100%), Bovine (97%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Fis1 is a 17 kDa integral membrane protein and a key component of the mitochondrial fission machinery. It contains a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain, and a C-terminal transmembrane domain.
As a human orthologue of Fis1p (S. cerevisiae), Fis1 localizes to the outer mitochondrial membrane and functions as a pro-apoptotic factor regulating mitochondrial fission. It interacts with DLP1 and Mdv1p to facilitate Dnm1p recruitment to the fission complex, inducing apoptosis.
Fis1 also plays a role in peroxisome growth and division. Loss of Fis1 inhibits apoptosis and leads to elongation of mammalian mitochondria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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