Thermo Fisher Scientific Nephrin Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Primary steroid resistant nephrotic syndrome (SRNS) is characterized by childhood onset of proteinuria and progression to end stage renal disease. Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss. Congenital nephrotic syndrome (CNS) is caused by mutations in NPHS1 (nephrin) or NPHS2.

Nephrin, a recently identified protein, is a member of a group of podocyte proteins that constitute a major component of the slit diaphragm, especially in the foot process. Nephrin, a cell adhesion molecule, may play a crucial role in maintaining the glomerular filtration barrier. Mutations in the gene for Nephrin reportedly lead to congenital nephrosis.

Three novel podocyte proteins — Podocin, Nephrin, and alpha Actinin 4 — have been identified in congenital and experimental models of proteinuria. The role of Nephrin in anti-apoptotic activity in podocyte slit diaphragm is believed to be associated with vascular endothelial derived growth factors (VEGF) signaling. Nephrin seems to play a role in the development or function of the kidney glomerular filtration barrier and may anchor the podocyte slit diaphragm to the actin cytoskeleton.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.