Thermo Fisher Scientific Humanin Polyclonal Antibody
Humanin 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며, Neuroprotective 및 Cytoprotective 연구에 활용 가능. Protein A로 정제된 고순도 항체로 안정적 저장 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Humanin, amino acids 1–24 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Humanin is a novel 24 amino acid polypeptide identified in Alzheimer’s disease-affected brain. It is 99% homologous to mitochondrial 16S ribosomal RNA and functions as a neuroprotective and cytoprotective factor.
It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer’s disease-related FAD genes by competitively inhibiting FPRL1 receptor access to beta-amyloids.
Humanin acts as an anti-apoptotic factor by binding to Bcl-2/Bax family proteins (Bax, Bak, Bid, BimEL), inhibiting their pro-apoptotic activity.
It activates the JAK/STAT signaling pathway and is regulated by TRIM11.
Additionally, Humanin interacts with IGFBP-3, blocking IGFBP-3-induced cell death in glioblastoma cells, and is also expressed in colon and testis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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