Thermo Fisher Scientific UBQLN4/CIP75/Ubiquilin 4 Polyclonal Antibody
Human Ubiquilin-4(CIP75)에 특이적인 Rabbit Polyclonal Antibody. Western Blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제. 단백질 분해 경로 연구에 활용 가능. 연구용 전용 시약.
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Thermo Fisher Scientific UBQLN4/CIP75/Ubiquilin 4 Polyclonal Antibody
Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 to 50 of Human Ubiquilin-4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The ubiquitin-proteosome pathway of protein degradation ensures proper cellular protein levels. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain-containing protein family is involved in proteosomal degradation.
CIP75, also known as Ubiquilin-4, interacts with proteins such as Ataxin-1 and Connexin-43, increasing their turnover rate. Overexpression of CIP75 reduces Connexin-43 half-life, while siRNA knockdown shows the opposite effect.
CIP75 has an N-terminal UbL domain that interacts with the 26S proteosome complex and a C-terminal UBA domain that mediates its interaction with Connexin-75. At least three isoforms of CIP75 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: A305-237A_Ubiquilin_4_Q9NRR5-1_Rabbit.svg)
(이미지: A305-237A_Ubiquilin_4_Q9NRR5-1_Rabbit_PDP.jpeg)
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