Thermo Fisher Scientific CTPS Polyclonal Antibody
CTPS 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC(P)에서 사용 가능. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 고순도(>95%)로 67 kDa 단백질 검출에 적합. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 80–130 of human CTPS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553498 |
Product Specific Information
- Detects endogenous CTPS protein at a molecular weight of approximately 67 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-1 and -2 (nuclear envelope spectrin repeat proteins), characterized by multiple clustered spectrin repeats, bipartite nuclear localization sequences, and a conserved C-terminal single transmembrane domain.
Transient transfection of EGFP-fusion constructs demonstrated localization to the nuclear membrane, with the C-terminal TM domain essential for perinuclear localization.
Nesprin-1 is developmentally regulated in both smooth and skeletal muscle and relocates from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation.
Nesprins may function as "dystrophins of the nucleus" to maintain nuclear organization and structural integrity.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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