Thermo Fisher Scientific PSMD2 Monoclonal Antibody (OTI1D1), Biotin, TrueMAB

Applications

ELISA (ELISA)

• Tested Dilution: 1:250–1:1,000

Luminex (LUM)

• Tested Dilution: Assay-dependent

Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Target Information

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of two complexes: a 20S core and a 19S regulator.

• The 20S core consists of four rings of 28 non-identical subunits (two rings of seven alpha subunits and two rings of seven beta subunits).
• The 19S regulator is composed of a base (six ATPase subunits and two non-ATPase subunits) and a lid (up to ten non-ATPase subunits).
  Proteasomes are abundant in eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
  A modified form, the immunoproteasome, processes class I MHC peptides.
  The PSMD2 gene encodes one of the non-ATPase subunits of the 19S regulator lid and may also participate in the TNF signaling pathway by interacting with the TNF type 1 receptor.
  A pseudogene has been identified on chromosome 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.