Thermo Fisher Scientific ROC2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening.
Aliquot contents and freeze at -20°C or below for extended storage.
Avoid cycles of freezing and thawing.
Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid.
Dilute only prior to immediate use.

This antibody reacts with human, mouse, C. elegans, and zebrafish ROC2.
Cross-reactivity may occur with ROC2 from other sources.
Sufficient sequence differences suggest that this antibody would not react with other RING box proteins such as ROC1 and APC11.

Target Information

The protein encoded by this gene is a highly conserved ring finger protein and an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are part of the protein degradation machinery important for cell cycle progression and signal transduction.
This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII).
Phosphorylation by CSNK2A1 promotes degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1 (CDKN1B).
Alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.