Thermo Fisher Scientific RNF128 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human RNF128. Recombinant protein control fragment (Product #RP-92127). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RNF128,uniProtId:Q8TEB7-1,ncbiNodeId:9606,antigenRange:300-422,antigenLength:428,antigenImageFileName:PA5-54054_RNF128_Q8TEB7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54054_RNF128_Q8TEB7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2646622

Product Specific Information

Immunogen sequence: HKTCVDPWLL EHRTCPMCKC DILKALGIEV DVEDGSVSLQ VPVSNEISNS ASSHEEDNRS ETASSGYASV QGTDEPPLEE HVQSTNESLQ LVNHEANSVA VDVIPHVDNP TFEEDETPNQ ETA

Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 92%.

Target Information

GRAIL is a type I transmembrane protein that localizes to the endocytic pathway and contains a PA (protease associated) domain and a RING-type zinc finger domain. It is a ubiquitin-protein isopeptide ligase (E3) necessary for the induction of CD4(+) T cell anergy in vivo and induced expression of this protein was observed in anergic CD4 (+) T cells, which suggested a role in the induction of anergic phenotype. It is differentially expressed in naturally occurring and peripherally induced CD25 (+) T regulatory cells and the expression is linked to the conversion of these cells to a regulatory phenotype. Expression of GRAIL in retrovirally transduced T cell hybridomas limits activation-induced IL-2 and IL-4 cytokine production. It also functions in the patterning of the dorsal ectoderm and sensitizes ectoderm to respond to neural-inducing signals.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.