Thermo Fisher Scientific KRT81 Polyclonal Antibody
Rabbit polyclonal antibody targeting human KRT81 protein. Validated for WB and IHC(P) applications. Detects endogenous KRT81 involved in hair keratin structure. Supplied as liquid, 0.8 mg/mL, stored at -20°C. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:15–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the N-terminus of human keratin 81 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635650 |
Product Specific Information
This antibody detects endogenous levels of total KRT81 protein.
Target Information
The KRT81 gene encodes a type II hair keratin, a basic protein that heterodimerizes with type I keratins to form hair and nails. Type II hair keratins are located on chromosome 12q13 and divided into two subfamilies based on structural similarity.
- Subfamily 1: KRTHB1, KRTHB3, KRTHB6 (highly related)
- Subfamily 2: KRTHB2, KRTHB4, KRTHB5 (less related)
All hair keratins are expressed in the hair follicle. KRT81, along with KRTHB3 and KRTHB6, is primarily found in the hair cortex. Mutations in KRT81 and KRTHB6 have been associated with monilethrix, a rare dominant hair disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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