Thermo Fisher Scientific QSK Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

SIK3 (QSK) is a serine/threonine-protein kinase belonging to the QIK subfamily. Phosphorylation of SIK3 by LKB1 through 14-3-3 binding enhances catalytic activity and leads to cytoplasmic punctate localization. Overexpression of SIK3 promotes G1/S cell cycle progression in ovarian cancer. Two mutation sites (H331L and A1103V) are frequently found in breast cancer. SIK3 acts as a novel tumor-associated antigen (TAA) and a positive regulator of mTOR signaling by triggering degradation of DEPTOR, an mTOR inhibitor. It is involved in dynamic regulation of mTOR signaling during chondrocyte differentiation in skeletogenesis and negatively regulates cAMP signaling, possibly via CRTC2/TORC2 and CRTC3/TORC3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.