Thermo Fisher Scientific QSK Polyclonal Antibody
Rabbit polyclonal antibody targeting Human SIK3 (QSK) region 900–950. Validated for WB and IP applications. Supplied as unconjugated liquid at 1 mg/mL concentration. Stored at 4°C and shipped on wet ice. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 900 and 950 of Human serine/threonine-protein kinase QSK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
SIK3 (QSK) is a serine/threonine-protein kinase belonging to the QIK subfamily. Phosphorylation of SIK3 by LKB1 through 14-3-3 binding enhances catalytic activity and leads to cytoplasmic punctate localization. Overexpression of SIK3 promotes G1/S cell cycle progression in ovarian cancer. Two mutation sites (H331L and A1103V) are frequently found in breast cancer. SIK3 acts as a novel tumor-associated antigen (TAA) and a positive regulator of mTOR signaling by triggering degradation of DEPTOR, an mTOR inhibitor. It is involved in dynamic regulation of mTOR signaling during chondrocyte differentiation in skeletogenesis and negatively regulates cAMP signaling, possibly via CRTC2/TORC2 and CRTC3/TORC3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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