Thermo Fisher Scientific JAK2 Polyclonal Antibody
JAK2 단백질을 표적하는 Rabbit Polyclonal 항체로 Western blot 및 IHC(P) 실험에 적합. Human과 Mouse 반응성 확인. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, 안정화제가 포함된 PBS buffer에 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific JAK2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide surrounding the epitope -EYYK- without phosphorylation of JAK2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
- Positive control: Mouse Muscle
- Cellular location: Cytoplasmic
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. Activation of JAKs can lead to phosphorylation of STAT (signal transducers and activators of transcription) proteins, which dimerize and translocate to the nucleus to modify transcription of numerous genes, including interferon-stimulated genes.
JAK2 is required for the IFN gamma-receptor complex initiation, while JAK1 functions as an amplifier. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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