Thermo Fisher Scientific MUC1 Monoclonal Antibody (E29)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-14077 targets Epithelial Membrane Antigen in IHC (P) applications and shows reactivity with Human samples.
The immunogen is a delipidated extract of human milk fat globule membranes.

Target Information

MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages.
It is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through intermediate forms generated by proteolysis and sequential addition of numerous O-linked glycans.
MUC1 is highly polymorphic, with each allele encoding a product containing 30–90 repeats, resulting in variable molecular weights.
It is abundantly expressed in >90% of breast carcinomas and metastases.
Overexpression and altered glycosylation of MUC1 have been associated with carcinomas.
Multiple alternatively spliced transcript variants of MUC1 have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.