Thermo Fisher Scientific PFKFB2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
RDKPTNNFPK NQTPVRMRRN SFTPLSSSNT IRRPRNYSVG SRPLKPLSPL RAQDMQEG

Target Information

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the γ phosphate of ATP, onto an acceptor amino acid in a substrate protein. Through this mechanism, protein kinases mediate most signal transduction in eukaryotic cells, regulating metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.
The protein kinase family, with more than 500 gene products, is one of the largest in eukaryotes. It is classified into 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
The AGC kinase group includes 63 kinases such as:

• Cyclic nucleotide-regulated protein kinases (PKA & PKG)
• Diacylglycerol-activated/phospholipid-dependent protein kinases (PKC)
• RAC/Akt protein kinase family
• ARK family (phosphorylates G protein-coupled receptors)
• RSK family (phosphorylates ribosomal protein S6)

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.