Thermo Fisher Scientific TDP43 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to react with Chicken and Orangutan

Target Information

TDP-43 (TAR DNA-binding protein 43) was first identified as a cellular protein that binds to the HIV-1 TAR DNA sequence motifs and acts as a transcriptional repressor of the HIV-1 LTR. It also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, likely through association with UG repeats at the 3′ splice site.

A hyperphosphorylated, ubiquitinated, and cleaved form of TDP-43, known as pathologic TDP-43, is the major disease protein in ubiquitin-positive, tau-negative, and alpha-synuclein-negative frontotemporal dementia (FTLD-U). TDP-43 is distinct from TRBP1, another RNA-binding protein that binds HIV-1 TAR RNA sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.