Thermo Fisher Scientific TDP43 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human TDP-43 protein. Suitable for WB, IHC, and IP applications. Recommended for use in neurodegenerative disease research. Supplied as liquid form, stored at 4°C. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:1,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 250 and 300 of Human TAR DNA-Binding Protein 43 (TDP-43, UniProt ID: Q13148-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Chicken and Orangutan
Target Information
TDP-43 (TAR DNA-binding protein 43) was first identified as a cellular protein that binds to the HIV-1 TAR DNA sequence motifs and acts as a transcriptional repressor of the HIV-1 LTR. It also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, likely through association with UG repeats at the 3′ splice site.
A hyperphosphorylated, ubiquitinated, and cleaved form of TDP-43, known as pathologic TDP-43, is the major disease protein in ubiquitin-positive, tau-negative, and alpha-synuclein-negative frontotemporal dementia (FTLD-U). TDP-43 is distinct from TRBP1, another RNA-binding protein that binds HIV-1 TAR RNA sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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